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KMID : 1094720210260040606
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Biotechnology and Bioprocess Engineering
2021 Volume.26 No. 4 p.606 ~ p.611
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Characterization and Anti-inflammatory Effects of Gamma-irradiation on Undaria pinnatifida Root Water Extracts
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Xu Xiaotong
Jeong So-Mi
Lee Ji-Eun
Kang Woo-Sin
Ryu Si-Hyeong
Byun Eui-Baek
Kim Kwang-Wook
Byun Eui-Hong
Ahn Dong-Hyun
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Abstract
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In this study, characterization and anti-inflammatory activity of Undaria pinnatifida root (UPR) water extracts treated by gamma (γ)-irradiation were investigated. The UPR powder was dissolved in distilled water to form UPR water extracts. Subsequently, they were irradiated with cobalt-60 γ-rays in a dose range from 3 to 20 kGy. In the reducing sugar and viscosity analyses, the reducing sugar content showed a two-fold increase at 20 kGy compared to the non-irradiated control, and UPR water extracts viscosity decreased with increasing irradiation dose. Using thin layer chromatography (TLC), UPR polysaccharides were degraded to monosaccharides after γ-irradiation treatment. Moreover, UPR water extracts treated with γ-irradiation inhibited the production of nitric oxide (NO) and pro-inflammatory cytokine (IL-6 and TNF-α) activity. Therefore, γ-irradiation not only degrades UPR water extracts polysaccharides, but also increases the anti-inflammatory activity of UPR water extracts.
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KEYWORD
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anti-inflammatory effect, degradation, Undaria pinnatifida root, γ-irradiation, polysaccharides
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